Hydrochloric Acid → HCID 67164302, compound

Participants

Reaction Steps

To a stirred solution of the product of Example 16A (250 mg, 0.60 mmol) in ethyl acetate (5 mL) and ethanol (0.2 mL), was added a solution of HCl in dioxane (4M; 0.33 mL, 1.32 mmol; Aldrich). After stirring the mixture for 6 hours, the resulting solid was collected by filtration to afford the title compound (284 mg, 0.50 mmol; 93%). 1H NMR (300 MHz, methanol-d4): δ 8.05 (2H, d, J=9 Hz), 7.54 (2H, d, J=2 Hz), 7.16 (2H, dd, J=9, 2 Hz), 4.46 (4H, t, J=5 Hz), 3.68 (4H, t, J=5 Hz), 3.44-3.35 (8H, q, J=7 Hz), 1.40 (12H, t, J=7 Hz). MS (DCI/NH3): m/z 415 (M+1)+. Anal. Calcd. for C24H34N2O2S.2HCl.0.2C4H8O2: C, 58.97; H, 7.50; N, 5.55. Found: C, 58.94; H, 7.43; N, 5.52.

Provenance & Evidence