HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilylacetylene → Methyl 5-((trimethylsilyl)ethynyl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Reactant | Methyl 5-bromopyridine-3-carboxylate | HCID 699336 | — |
| Product | Methyl 5-((trimethylsilyl)ethynyl)nicotinate | HCID 53821751 | 13.6% |
Reaction Steps
Under the conditions of example 21 B, 5 g of 5-bromonicotinic acid methyl ester is reacted with 2.43 g of trimethylsilylacetylene, worked up, and the crude product is chromatographed on silica gel with hexane/0-5% ethyl acetate. 734 mg of 5-(2-trimethlsilylethinyl)-nicotinic acid methyl ester is obtained as oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624943 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-b32f6a6c03b1401f8f6ebe00916729cb |
| Source note | uspto-grants-1997_04 |