反应详情

温度

85 °C

A mixture of 3-Boc-3,7-diazabicyclo[3.3.0]octane (340 mg, 1.6 mmol; see WO 0181347), 2-bromofluorene (0.47 g, 1.9 mmol), tris(dibenzylideneacetone)dipalladium (0) (Pd2(dba)3; 44 mg, 0.048 mmol; Strem), racemic-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP; 50 mg, 0.080 mmol; Strem) and Cs2CO3 (1.0 g, 3.2 mmol; Aldrich) in toluene (25 mL) in a sealed tube was warmed to 85° C. and stirred for 18 h. The material was cooled to ambient temperature, filtered, concentrated under reduced pressure and purified by flash chromatography (silica gel, 50% gradient of EtOAc in hexanes) to afford the title compound (350 mg, 0.93 mmol; 58% yield): MS (DCI/NH3) m/z 377 (M+H)+.

1. temperatureThe material was cooled to ambient temperature
2. filtrationfiltered
3. concentrationconcentrated under reduced pressure
4. custompurified by flash chromatography (silica gel, 50% gradient of EtOAc in hexanes)