HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → Methyl 5-ethynylnicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | Methyl 5-((trimethylsilyl)ethynyl)nicotinate | HCID 53821751 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 5-ethynylnicotinate | HCID 53898384 | 61.2% |
Reaction Steps
Under the conditions of example 21 C, 464 mg of 5-(2-trimethylsilylethinyl)-nicotinic acid methyl ester is reacted with 2 ml of a 1-molar solution of tetrabutylammonium fluoride in tetrahydrofuran, worked up, and the residue is chromatographed on silica gel with hexane/0-7% ethyl acetate. 196 mg of 5-ethinylnicotinic acid methyl ester is obtained as oily crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624943 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-89d4abab64bb4dceb596cd3f470fa680 |
| Source note | uspto-grants-1997_04 |