Methyl 2-bromo-2-methylpropionate → methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate

HRID 553084Notes

Reaction equation

HRID 553084 reaction equation
[N+:1]([C:4]1[N:5]=[CH:6][NH:7][CH:8]=1)([O-:3])=[O:2].[CH3:9][O:10][C:11](=[O:16])[C:12](Br)([CH3:14])[CH3:13]>>[CH3:9][O:10][C:11](=[O:16])[C:12]([CH3:14])([N:7]1[CH:8]=[C:4]([N+:1]([O-:3])=[O:2])[N:5]=[CH:6]1)[CH3:13]

Participants

3

Reactant 2

HCID 90097Methyl 2-bromo-2-methylpropionateHCID 178526856HCID 178526856, compound

Product 1

HCID 67164903methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate

Procedure

4-nitroimidazole was alkylated with 2-Bromo-2-methyl-propionic acid methyl ester to provide the title compound: 1H NMR (400 MHz, CDCl3) 1.89 (s, 6H), 3.78 (s, 3H), 7.59 (d, 1H, J=1.7 Hz), 7.89 (s, 1H, J=1.7 Hz); MS 214.1 m/z (M+1).

Sources & evidence

ORD record
ord-72b72b4b265940fea55e4d377a16c53d
Source dataset
uspto-grants-2011_05
Patent number
US07951958B2

Reaction notes

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