HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 1-(2-Methoxy-1,1-dimethyl-ethyl)-4-nitro-1H-imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate | HCID 67164903 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(2-Methoxy-1,1-dimethyl-ethyl)-4-nitro-1H-imidazole | HCID 67164433 | — |
Reaction Steps
2-Methyl-2-(4-nitro-imidazol-1-yl)-propionic acid methyl ester was reduced using sodium borohydride in methanol and the resultant alcohol was alkylated with methyl iodide using sodium hydride as base to provide the title compound: H1 NMR (400 MHz, CDCl3) 1.53 (s, 6H), 3.25 (s, 3H), 3.38 (s, 2H), 7.53 (s, 1H), 7.88 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951958B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-fe74506628a045ec9ed2a89da8c179dd |
| Source note | uspto-grants-2011_05 |