HRID55309

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID19957419

未命名化合物

结构：COC(=O)CCc1nc(I)ccc1OCCCC/C=C/c1ccc(OC)cc1

HCID86750763

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CCc1nc(C#Cc2cccc(NS(=O)(=O)C(F)(F)F)c2)ccc1OCCCC/C=C/c1ccc(OC)cc1

HCID67703872

未命名化合物

收率 32.7%

PROCEDURE

实验过程

Under the conditions of example 5 A, 370 mg of crude N-(3-ethinylphenyl)-1,1,1-trifluoromethanesulfonamide is reacted with 735 mg of 3-{6-iodo-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with hexane/0-20% ethyl acetate. 299 mg of 3-{3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-6-[2-(3-trifluoromethanesulfonamidophenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester is obtained as oil.

WORKUP

后处理

customthe crude product is chromatographed on silica gel with hexane/0-20% ethyl acetate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-92fce624ee944e138732a081936d55d8
来源数据集: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05624943
来源说明: uspto-grants-1997_04

反应 SMILES

[C:1]([C:3]1[CH:4]=[C:5]([NH:9][S:10]([C:13]([F:16])([F:15])[F:14])(=[O:12])=[O:11])[CH:6]=[CH:7][CH:8]=1)#[CH:2].[CH3:17][O:18][C:19](=[O:44])[CH2:20][CH2:21][C:22]1[C:27]([O:28][CH2:29][CH2:30][CH2:31][CH2:32]/[CH:33]=[CH:34]/[C:35]2[CH:40]=[CH:39][C:38]([O:41][CH3:42])=[CH:37][CH:36]=2)=[CH:26][CH:25]=[C:24](I)[N:23]=1>>[CH3:17][O:18][C:19](=[O:44])[CH2:20][CH2:21][C:22]1[C:27]([O:28][CH2:29][CH2:30][CH2:31][CH2:32]/[CH:33]=[CH:34]/[C:35]2[CH:36]=[CH:37][C:38]([O:41][CH3:42])=[CH:39][CH:40]=2)=[CH:26][CH:25]=[C:24]([C:2]#[C:1][C:3]2[CH:8]=[CH:7][CH:6]=[C:5]([NH:9][S:10]([C:13]([F:16])([F:14])[F:15])(=[O:12])=[O:11])[CH:4]=2)[N:23]=1