2,6-Dimethylmorpholine, cis- → 2,6-Dimethyl-4-[2-methyl-2-(4-nitro-imidazol-1-yl)-propyl]-morpholine

HRID 553096Notes

Reaction equation

HRID 553096 reaction equation
[CH3:1][C:2]([N:6]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[N:8]=[CH:7]1)([CH3:5])[CH:3]=O.[CH3:14][C@H:15]1[O:20][C@@H:19]([CH3:21])[CH2:18][NH:17][CH2:16]1>>[CH3:21][CH:19]1[O:20][CH:15]([CH3:14])[CH2:16][N:17]([CH2:3][C:2]([CH3:1])([N:6]2[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[N:8]=[CH:7]2)[CH3:5])[CH2:18]1

Participants

3

Reactant 2

HCID 6415002,6-Dimethylmorpholine, cis-HCID 866008092-Methyl-2-(4-nitro-imidazol-1-yl)-propionaldehyde

Product 1

HCID 671640432,6-Dimethyl-4-[2-methyl-2-(4-nitro-imidazol-1-yl)-propyl]-morpholine

Procedure

2-Methyl-2-(4-nitro-imidazol-1-yl)-propionaldehyde was reacted with cis-2,6-dimethyl morpholine to provide the title compound: C13 NMR (100 MHz, CDCl3) 19.0, 25.7, 60.8, 61.5, 68.5, 72.0, 118.0, 134.5; MS m/z 283.2 (M+1).

Sources & evidence

ORD record
ord-60f66c6f67ac41fcb6c47d3a62c8defd
Source dataset
uspto-grants-2011_05
Patent number
US07951958B2

Reaction notes

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