HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-pentynoate → 5-[3-Hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-4-pentynoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-pentynoate | HCID 543061 | — |
| Reactant | 3-(3-Hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester | HCID 54475019 | — |
| Product | 5-[3-Hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-4-pentynoic acid methyl ester | HCID 54284171 | 84.3% |
Reaction Steps
Under the conditions of example 5A, 2 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 0.8 g of 4-pentynoic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with hexane/0-30% ethyl acetate. 1.6 g of 5-[3-hydroxy-2-(2-methoxycarbonylethyl)-6-pyridyl]-4-pentynoic acid methyl ester of melting point 119°-121° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624943 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-6f7f522312714d42969d4a45c59ccb43 |
| Source note | uspto-grants-1997_04 |