HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-Hydroxy-3-methylbutanoic acid → 3-{4-[2-(2-Hydroxy-3-methyl-butyrylamino)-pentanoylamino]-imidazol-1-yl}-3-methyl-butyric acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-Hydroxy-3-methylbutanoic acid | HCID 853180 | — |
| Reactant | 3-[4-(2-Amino-pentanoylamino)-imidazol-1-yl]-3-methyl-butyric acid methyl ester | HCID 67165360 | — |
| Product | 3-{4-[2-(2-Hydroxy-3-methyl-butyrylamino)-pentanoylamino]-imidazol-1-yl}-3-methyl-butyric acid methyl ester | HCID 11567431 | — |
Reaction Steps
3-[4-(2-Amino-pentanoylamino)-imidazol-1-yl]-3-methyl-butyric acid methyl ester was coupled with (S)-2-hydroxy-3-methyl-butyric acid to provide the title compound: C13 NMR (100 MHz, CDCl3) 13.9, 16.0, 19.1, 19.4, 28.1, 32.2, 35.5, 47.1, 51.9, 52.7, 56.4, 105.1, 131.1, 137.6, 169.6, 170.0, 174.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951958B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-32fdaabd6250458f800f79c0e8073d9b |
| Source note | uspto-grants-2011_05 |