3,5-Difluorophenylacetic acid → 2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid [1-(1-ethyl-Propyl)-1H-imidazol-4-yl]-amide

Participants

Role	Name	HCID	Charge
Reactant	3,5-Difluorophenylacetic acid	HCID 145424	—
Reactant	2-Amino-pentanoic acid [1-(1-ethyl-propyl)-1H-imidazol-4-yl]-amide	HCID 67165041	—
Product	2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid [1-(1-ethyl-Propyl)-1H-imidazol-4-yl]-amide	HCID 11640075	—

Reaction Steps

2-Amino-pentanoic acid [1-(1-ethyl-propyl)-1H-imidazol-4-yl]-amide was coupled with (3,5-Difluoro-phenyl)-acetic acid to provide the title compound: C13 NMR (100 MHz, CDCl3) 10.7, 10.8, 13.9, 18.9, 28.8, 36.1, 43.0, 53.0, 62.9, 102.5, 102.7, 103.3, 104.5, 112.3, 112.4, 112.5, 112.6, 132.9, 138.0, 138.9, 161.9, 164.3, 164.5, 169.2, 169.5; MS 407.23 m/z (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07951958B2
Source dataset	uspto-grants-2011_05
ORD ID	ord-0052327575d64916b2b8926cf9e5d651
Source note	uspto-grants-2011_05