3,5-Difluorophenylacetic acid → HCID 11705590, compound

HRID 553124Notes

Reaction equation

HRID 553124 reaction equation
[CH3:1][C:2]([N:10]1[CH:14]=[C:13]([NH:15][C:16](=[O:23])[CH:17]([NH2:22])[CH2:18][CH:19]([CH3:21])[CH3:20])[N:12]=[CH:11]1)([CH3:9])[CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][CH2:5]1.[F:24][C:25]1[CH:26]=[C:27]([CH2:32][C:33](O)=[O:34])[CH:28]=[C:29]([F:31])[CH:30]=1>>[CH3:1][C:2]([N:10]1[CH:14]=[C:13]([NH:15][C:16](=[O:23])[CH:17]([NH:22][C:33](=[O:34])[CH2:32][C:27]2[CH:26]=[C:25]([F:24])[CH:30]=[C:29]([F:31])[CH:28]=2)[CH2:18][CH:19]([CH3:20])[CH3:21])[N:12]=[CH:11]1)([CH3:9])[CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67163291HCID 67163291, compound

Product 1

HCID 11705590HCID 11705590, compound

Procedure

2-Amino-4-methyl-pentanoic acid [1-(1,1-dimethyl-2-pyrrolidin-1-yl-ethyl)-1H-imidazol-4-yl]-amide was coupled with (3,5-Difluoro-phenyl)-acetic acid to provide the title compound: C13 NMR (100 MHz, CDCl3) 22.5, 22.9, 24.2, 25.0, 26.6, 26.7, 42.9, 43.1, 51.9, 56.0, 59.3, 67.3, 102.9, 105.5, 112.3, 112.6, 131.9, 137.4, 169.1, 169.4; MS m/z 476.3 (M+1).

Sources & evidence

ORD record
ord-7a335306d96a4e68b5af0f8df6cacfd1
Source dataset
uspto-grants-2011_05
Patent number
US07951958B2

Reaction notes

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