2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid → 2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid {1-[1-(2,2-dimethyl-propyl)-Pyrrolidin-3-yl]-1H-imidazol-4-yl}-amide

Participants

Role	Name	HCID	Charge
Reactant	2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid	HCID 21942986	—
Reactant	1-[1-(2,2-Dimethyl-propyl)-pyrrolidin-3-yl]-1H-imidazol-4-ylamine	HCID 67164806	—
Product	2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid {1-[1-(2,2-dimethyl-propyl)-Pyrrolidin-3-yl]-1H-imidazol-4-yl}-amide	HCID 11648572	—

Reaction Steps

1-[1-(2,2-Dimethyl-propyl)-pyrrolidin-3-yl]-1H-imidazol-4-ylamine was coupled with 2-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid to afford the title compound: C13 NMR (100 MHz, CDCl3) 14.0, 18.9, 28.6, 33.0, 33.4, 35.9, 43.1, 53.1, 55.7, 57.3, 63.5, 68.3, 102.6, 102.8, 103.1, 106.6, 112.3, 112.5, 112.6, 132.1, 137.7, 138.8, 161.9, 164.5, 169.1; MS m/z 476.2 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07951958B2
Source dataset	uspto-grants-2011_05
ORD ID	ord-15f233ba37444dc99264c7cbe202aa87
Source note	uspto-grants-2011_05