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HRID 553132作成日：2026年10月26日

6,8-Difluoro-2-tetralone → 2-{4-[2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoylamino]-imidazol-1-yl}-2-methyl-propionic acid methyl ester

https://huagongshe.com/reaction/553132

反応式

関与物質

役割名称HCID仕込み量
反応物6,8-Difluoro-2-tetraloneHCID 4076431—
反応物2-[4-(2-Amino-pentanoylamino)-imidazol-1-yl]-2-methyl-propionic acid methyl esterHCID 67165426—
生成物2-{4-[2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoylamino]-imidazol-1-yl}-2-methyl-propionic acid methyl esterHCID 11705041—

反応手順

2-[4-(2-Amino-pentanoylamino)-imidazol-1-yl]-2-methyl-propionic acid methyl ester was reacted with 6,8-Difluoro-3,4-dihydro-1H-naphthalen-2-one to provide the title compound: C13 NMR (100 MHz, CD3OH) 13.0, 18.1, 24.5, 25.4, 25.8, 27.5, 32.8, 53.1, 53.2, 57.9, 64.7, 100.8, 101.1, 109.9, 110.4, 110.8, 115.8, 128.4, 131.6, 132.3, 139.1, 139.3, 159.5, 160.2, 166.8, 171.2; MS 449.3 m/z (M+1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07951958B2
出典データセットuspto-grants-2011_05
ORD IDord-c0f8a863e6fe4bb186248a6c7aa5aecf
出典メモuspto-grants-2011_05