Sodium Hydroxide → HCID 19957436, compound

HRID 55314Notes

Reaction equation

HRID 55314 reaction equation
C[O:2][C:3](=[O:33])[CH2:4][CH2:5][C:6]1[C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16]/[CH:17]=[CH:18]/[C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)=[CH:10][CH:9]=[C:8]([CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][OH:32])[N:7]=1.[OH-].[Na+]>CO>[OH:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][C:8]1[N:7]=[C:6]([CH2:5][CH2:4][C:3]([OH:33])=[O:2])[C:11]([O:12][CH2:13][CH2:14][CH2:15][CH2:16]/[CH:17]=[CH:18]/[C:19]2[CH:20]=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=2)=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 677037863-{6-(5-hydroxypentyl)-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester

Product 1

HCID 19957436HCID 19957436, compoundYield 83.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Under the conditions of example 3 C, 400 mg of 3-{6-(5-hydroxypentyl)-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester in 20 ml of methanol is saponified with 12 ml of 2n sodium hydroxide solution and worked up. 322 mg of the title compound is obtained as oil.

Sources & evidence

ORD record
ord-0dcdf700c2f24eb1827b1265bd328570
Source dataset
uspto-grants-1997_04
Patent number
US05624943

Reaction notes

Loading…