3-Ethynylbenzoic acid methyl ester → 3-{3-Hydroxy-6-[2-(3-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	3-Ethynylbenzoic acid methyl ester	HCID 11275159	—
Edukt	3-(3-Hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester	HCID 54475019	—
Produkt	3-{3-Hydroxy-6-[2-(3-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester	HCID 54492341	46,2%

Reaktionsschritte

Under the conditions of example 5A, 9.2 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 4.8 g of 3-ethinylbenzoic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with hexane/0-20% ethyl acetate. 4.7 g of 3-{3-hydroxy-6-[2-(3-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester of melting point 125°-127° C. is obtained.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05624943
Quelldatensatz	uspto-grants-1997_04
ORD ID	ord-544f5b679e534578886630149d855777
Quellennotiz	uspto-grants-1997_04