HCID 58101931, compound → HCID 67163808, compound

HRID 553151Notes

Reaction equation

HRID 553151 reaction equation
[CH3:1][C:2]([N:10]1[CH:14]=[C:13]([NH:15][C:16](=[O:22])[CH:17]([NH2:21])[CH2:18][CH2:19][CH3:20])[N:12]=[CH:11]1)([CH3:9])[CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][CH2:5]1.[CH:23]([C:26]1[CH:27]=[C:28]2[C:33](=[CH:34][CH:35]=1)[CH2:32][C:31](=O)[CH2:30][CH2:29]2)([CH3:25])[CH3:24]>>[CH3:1][C:2]([N:10]1[CH:14]=[C:13]([NH:15][C:16](=[O:22])[CH:17]([NH:21][CH:31]2[CH2:30][CH2:29][C:28]3[C:33](=[CH:34][CH:35]=[C:26]([CH:23]([CH3:25])[CH3:24])[CH:27]=3)[CH2:32]2)[CH2:18][CH2:19][CH3:20])[N:12]=[CH:11]1)([CH3:9])[CH2:3][N:4]1[CH2:8][CH2:7][CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 58101931HCID 58101931, compoundHCID 671642262-Amino-pentanoic acid [1-(1,1-dimethyl-2-pyrrolidin-1-yl-ethyl)-1H-imidazol-4-yl]-amide

Product 1

HCID 67163808HCID 67163808, compound

Procedure

2-Amino-pentanoic acid [1-(1,1-dimethyl-2-pyrrolidin-1-yl-ethyl)-1H-imidazol-4-yl]-amide was reacted with 6-Isopropyl-3,4-dihydro-1H-naphthalen-2-one to provide the title compound: C13 NMR (100 MHz, CDCl3) 14.2, 19.5, 19.6, 24.3, 26.6, 26.7, 28.2, 28.5, 29.6, 30.6, 33.9, 36.4, 36.5, 37.3, 53.4, 53.8, 56.0, 59.1, 60.4, 60.8, 67.3, 104.7, 124.2, 126.7, 126.8, 129.5, 129.6, 131.1, 132.2, 132.7, 135.7, 136.0, 137.3, 146.7, 146.8, 172.5, 172.6; MS m/z 480.5 (M+1).

Sources & evidence

ORD record
ord-0df22d6d075446e69075f59eca73dc15
Source dataset
uspto-grants-2011_05
Patent number
US07951958B2

Reaction notes

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