6,8-Difluoro-2-tetralone → HCID 11569653, compound

HRID 553159Notes

Reaction equation

HRID 553159 reaction equation
[CH3:1][C:2]([N:12]1[CH:16]=[C:15]([NH:17][C:18](=[O:24])[CH:19]([NH2:23])[CH2:20][CH2:21][CH3:22])[N:14]=[CH:13]1)([CH3:11])[CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.[F:25][C:26]1[CH:27]=[C:28]2[C:33](=[C:34]([F:36])[CH:35]=1)[CH2:32][C:31](=O)[CH2:30][CH2:29]2>>[CH3:1][C:2]([N:12]1[CH:16]=[C:15]([NH:17][C:18](=[O:24])[CH:19]([NH:23][CH:31]2[CH2:30][CH2:29][C:28]3[C:33](=[C:34]([F:36])[CH:35]=[C:26]([F:25])[CH:27]=3)[CH2:32]2)[CH2:20][CH2:21][CH3:22])[N:14]=[CH:13]1)([CH3:11])[CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][O:8][CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 40764316,8-Difluoro-2-tetraloneHCID 67165351HCID 67165351, compound

Product 1

HCID 11569653HCID 11569653, compound

Procedure

2-Amino-pentanoic acid [1-(1,1-dimethyl-3-morpholin-4-yl-propyl)-1H-imidazol-4-yl]-amide was reacted with 6,8-Difluoro-3,4-dihydro-1H-naphthalen-2-one to provide the title compound: 13C NMR 14.2, 19.5, 19.6, 28.2, 28.3, 28.5, 28.6, 28.6, 28.7, 28.8, 29.7, 29.8, 30.8, 36.5, 36.6, 39.8, 52.3, 52.7, 54.0, 57.2, 57.3, 60.3, 60.8, 67.1, 100.8, 101.1, 101.3, 104.6, 104.7, 110.5, 110.6, 110.8, 110.9, 130.5, 137.6, 137.7, 139.9, 159.7, 162.3, 172.3, 172.5; MS m/z 504.2 (M+1).

Sources & evidence

ORD record
ord-bc794ee7709e4bf290c946c49b9cd0dd
Source dataset
uspto-grants-2011_05
Patent number
US07951958B2

Reaction notes

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