HRID55316

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15472944

未命名化合物

结构：COC(=O)CCc1nc(C#Cc2cccc(C(=O)OC)c2)ccc1O

HCID54492341

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CCc1nc(CCc2cccc(C(=O)OC)c2)ccc1OCCCC/C=C/c1ccc(OC)cc1

HCID67703738

未命名化合物

收率 57.4%

PROCEDURE

实验过程

Under the conditions of example 1 D, 1.24 g of 3-{3-hydroxy-6-[2-(3-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester is reacted with 970 mg of (1E)-6-bromo-1-(4-methoxyphenyl)-1-hexene, worked up, and the crude product is chromatographed on silica gel with hexane/0-7.5% ethyl acetate. 1.1 g of 3-{6-[2-(3-methoxycarbonylphenyl)-ethyl]-3-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-2-pyridyl}-propionic acid methyl ester is obtained as colorless oil.

WORKUP

后处理

customthe crude product is chromatographed on silica gel with hexane/0-7.5% ethyl acetate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3c94ccd248854895bdee1e0de3709be5
来源数据集: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05624943
来源说明: uspto-grants-1997_04

反应 SMILES

[CH3:1][O:2][C:3](=[O:25])[CH2:4][CH2:5][C:6]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8]([C:13]#[C:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([O:23][CH3:24])=[O:22])[CH:16]=2)[N:7]=1.Br[CH2:27][CH2:28][CH2:29][CH2:30]/[CH:31]=[CH:32]/[C:33]1[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=1>>[CH3:1][O:2][C:3](=[O:25])[CH2:4][CH2:5][C:6]1[C:11]([O:12][CH2:27][CH2:28][CH2:29][CH2:30]/[CH:31]=[CH:32]/[C:33]2[CH:34]=[CH:35][C:36]([O:39][CH3:40])=[CH:37][CH:38]=2)=[CH:10][CH:9]=[C:8]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([O:23][CH3:24])=[O:22])[CH:16]=2)[N:7]=1