6,8-Difluoro-2-tetralone → HCID 11511372, compound

HRID 553164Notes

Reaction equation

HRID 553164 reaction equation
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[C:13]([NH:15][C:16](=[O:22])[CH:17]([NH2:21])[CH2:18][CH2:19][CH3:20])[N:12]=[CH:11]2)=[CH:6][CH:5]=1.[F:24][C:25]1[CH:26]=[C:27]2[C:32](=[C:33]([F:35])[CH:34]=1)[CH2:31][C:30](=O)[CH2:29][CH2:28]2>>[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH:14]=[C:13]([NH:15][C:16](=[O:22])[CH:17]([NH:21][CH:30]3[CH2:29][CH2:28][C:27]4[C:32](=[C:33]([F:35])[CH:34]=[C:25]([F:24])[CH:26]=4)[CH2:31]3)[CH2:18][CH2:19][CH3:20])[N:12]=[CH:11]2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 40764316,8-Difluoro-2-tetraloneHCID 67164680HCID 67164680, compound

Product 1

HCID 11511372HCID 11511372, compound

Procedure

4-[4-(2-Amino-pentanoylamino)-imidazol-1-yl]-benzoic acid methyl ester was reacted with 6,8-Difluoro-3,4-dihydro-1H-naphthalen-2-one to provide the title compound: MS m/z 483.2 (M+1).

Sources & evidence

ORD record
ord-426b3871985a4cbeb7b77fa917ef3716
Source dataset
uspto-grants-2011_05
Patent number
US07951958B2

Reaction notes

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