反应详情

温度

80 °C

A mixture of 2-bromo-1-(4-fluorophenylmethyl)-1H-benzimidazole (10.07 g) and 1,5-diazacyclooctane (5.60 g) was heated at 80° C. for 1 hour. To the reaction mixture was added distilled water (300 ml), and the mixture was extracted with methylene chloride (300 ml). The extract was washed with water, and dried over anhydrous MgSO4. The solvent was removed under reduced pressure to give 1-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-yl]-1,5-diazacyclooctane (12.1 g) as a colorless oily liquid.

1. additionTo the reaction mixture was added
2. distillationdistilled water (300 ml)
3. extractionthe mixture was extracted with methylene chloride (300 ml)
4. washThe extract was washed with water
5. dry with materialdried over anhydrous MgSO4
6. customThe solvent was removed under reduced pressure