3,5-Difluorophenylacetic acid → HCID 11663161, compound

HRID 553177Notes

Reaction equation

HRID 553177 reaction equation
[CH3:1][C:2]([CH3:24])([CH3:23])[CH2:3][N:4]1[CH2:9][C:8]([CH3:11])([CH3:10])[N:7]2[CH:12]=[N:13][C:14]([NH:15][C:16](=[O:22])[CH:17]([NH2:21])[CH2:18][CH2:19][CH3:20])=[C:6]2[CH2:5]1.[F:25][C:26]1[CH:27]=[C:28]([CH2:33][C:34](O)=[O:35])[CH:29]=[C:30]([F:32])[CH:31]=1>>[CH3:24][C:2]([CH3:23])([CH3:1])[CH2:3][N:4]1[CH2:9][C:8]([CH3:10])([CH3:11])[N:7]2[CH:12]=[N:13][C:14]([NH:15][C:16](=[O:22])[CH:17]([NH:21][C:34](=[O:35])[CH2:33][C:28]3[CH:27]=[C:26]([F:25])[CH:31]=[C:30]([F:32])[CH:29]=3)[CH2:18][CH2:19][CH3:20])=[C:6]2[CH2:5]1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67164461HCID 67164461, compound

Product 1

HCID 11663161HCID 11663161, compound

Procedure

Following general coupling procedure A, 2-amino-pentanoic acid [7-(2,2-dimethyl-propyl)-5,5-dimethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazin-1-yl]-amide is coupled with (3,5-difluoro-phenyl)-acetic acid to provide the title compound: Diagnostic C13 NMR (100 MHz, CDCl3) 13.5, 18.9, 27.4, 28.1, 28.6, 33.5, 35.4, 43.1, 52.8, 53.2, 56.2, 65.7, 69.9, 102.9, 112.3, 112.6, 117.4, 129.2, 169.9; MS m/z 490.5 (M+1).

Sources & evidence

ORD record
ord-03f798643d5a4df1be85408bf1a83824
Source dataset
uspto-grants-2011_05
Patent number
US07951958B2

Reaction notes

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