2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid → HCID 11503263, compound

HRID 553183Notes

Reaction equation

HRID 553183 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([F:12])[CH:11]=1)[CH2:8][CH:7]([NH:13][CH:14]([CH2:18][CH2:19][CH3:20])[C:15]([OH:17])=O)[CH2:6][CH2:5]2.[CH3:21][N:22]([CH3:33])[CH2:23][C:24]([N:27]1[CH:31]=[C:30]([NH2:32])[N:29]=[CH:28]1)([CH3:26])[CH3:25]>>[CH3:33][N:22]([CH3:21])[CH2:23][C:24]([N:27]1[CH:31]=[C:30]([NH:32][C:15](=[O:17])[CH:14]([NH:13][CH:7]2[CH2:6][CH2:5][C:4]3[C:9](=[C:10]([F:12])[CH:11]=[C:2]([F:1])[CH:3]=3)[CH2:8]2)[CH2:18][CH2:19][CH3:20])[N:29]=[CH:28]1)([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 211128022-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acidHCID 67164922HCID 67164922, compound

Product 1

HCID 11503263HCID 11503263, compound

Procedure

Following the procedure for Example 86, 2-(6,8-Difluoro-1,2,3,4-tetrahydro-naphthalen-2-ylamino)-pentanoic acid (diastereomer 2) was reacted with 1-(2-Dimethylamino-1,1-dimethyl-ethyl)-1H-imidazol-4-ylamine to afford the title compound: C13 NMR (100 MHz, CDCl3) 14.1, 19.5, 26.2, 28.2, 28.8, 28.9, 29.8, 36.6, 48.0, 52.8, 59.0, 60.9, 70.0, 100.8, 101.1, 101.3, 104.6, 110.7, 110.8, 131.3, 137.4, 172.3; MS m/z 448.3 (M+1).

Sources & evidence

ORD record
ord-c49c67e3682c4d37820e1d0a4809d6ab
Source dataset
uspto-grants-2011_05
Patent number
US07951958B2

Reaction notes

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