Pyrrolidine → HCID 67165963, compound

Participants

Reaction Steps

Pyrrolidine (0.75 g, 10.6 mmol) was added to an N,N-dimethylacetamide (15 ml) solution of 5-chloromethylfuran-2-carboxylic acid ethyl ester (1.0 g, 5.3 mmol), and stirred at room temperature for 24 hours. The solvent was evaporated, and the residue was purified using medium pressure silica gel flash column chromatography (NH silica gel, chloroform:methanol=98:2) to afford 5-pyrrolidine-1-yl-methyl-furan-2-carboxylic acid ethyl ester (793 mg, 67%).

Provenance & Evidence