Pyridine → HCID 67166415, compound

Participants

Reaction Conditions

Reaction Steps

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (63 mg, 0.33 mmol) and 1-hydroxybenzotriazole monohydrate (51 mg, 0.33 mmol) were added to a pyridine (4 ml) solution of the 5-(5-benzoylbenzimidazol-2-yl)-furan-2-carboxylic acid (100 mg, 0.30 mmol) obtained in Example 57. Pyrrolidine (21 mg, 0.30 mmol) was added and then heated. The reaction mixture was stirred at 70° C. for 6 hours, and then allowed to cool to room temperature with stirring. The solvent was evaporated, and the residue was purified using medium pressure silica gel flash column chromatography (NH silica gel, chloroform:methanol=98:2) to afford (4-(5-benzoylbenzimidazol-2-yl)-2-furanylcarbonyl)pyrrolidine (102 mg, 88%) as a brown oil.

Provenance & Evidence