HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 553273Generated: November 1, 2026
Water → (+)-Methyl 5-oxo-3-(2,4,6-trimethoxyphenyl)pyrrolidine-2-carboxylate
https://huagongshe.com/reaction/553273
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | (+)-Dimethyl 5-oxo-3-(2,4,6-trimethoxyphenyl)pyrrolidine-2,4-dicarboxylate | HCID 67164784 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | (+)-Methyl 5-oxo-3-(2,4,6-trimethoxyphenyl)pyrrolidine-2-carboxylate | HCID 67165578 | — |
Reaction Steps
(+)-Dimethyl 5-oxo-3-(2,4,6-trimethoxyphenyl)pyrrolidine-2,4-dicarboxylate (4.0 g, 0.0109 mol) was dissolved in N-methylpyrrolidone (15 mL). Sodium chloride (0.631 g, 0.0109 mol) and water (0.196 mL, 0.0109 mol) were added and the reaction mixture was heated to 170° C. for 5 hours. The reaction mixture was poured on ice (50 g) and the solid was filtered and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07951961B2 |
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| Source dataset | uspto-grants-2011_05 |
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| ORD ID | ord-44498d565b1d4b958093f38155574885 |
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| Source note | uspto-grants-2011_05 |
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