反应详情

Acetyl chloride (5 mL) was added cautiously to solution of (4-hydroxymethylphenyl)acetic acid (5.78 g) in methanol (200 mL), stirred for 18 hours and evaporated. The residue was dissolved in dichloromethane (100 mL) and treated with manganese (IV) oxide (29.47 g), stirred for 18 hours and filtered through Celite. The filter pad was washed with dichloromethane and the combined filtrates evaporated. Purification on silica, eluting with 20% diethyl ether in iso-hexane, afforded the subtitle compound as a white solid (3.60 g).

1. customevaporated
2. dissolutionThe residue was dissolved in dichloromethane (100 mL)
3. additiontreated with manganese (IV) oxide (29.47 g)
4. stirringstirred for 18 hours
5. filtrationfiltered through Celite
6. washThe filter pad was washed with dichloromethane
7. customthe combined filtrates evaporated
8. customPurification on silica
9. washeluting with 20% diethyl ether in iso-hexane