反应详情

Manganese(IV) oxide (1.43 g) was added to a solution of 2-(2-hydroxymethyl-phenyl)-ethanol (0.5 g) in dichloromethane (25 mL) and stirred for 18 hours under nitrogen. The reaction was filtered through celite, the filter pad washed with dichloromethane (2×20 mL), and the combined filtrates evaporated. Purification on silica, eluting with a gradient of iso-hexane:ethyl acetate [1:0 to 4:1], afforded the subtitle compound as a yellow oil (263 mg).

1. filtrationThe reaction was filtered through celite
2. washthe filter pad washed with dichloromethane (2×20 mL)
3. customthe combined filtrates evaporated
4. customPurification on silica
5. washeluting with a gradient of iso-hexane