HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → Methyl 2-(4-bromophenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Benzeneacetic acid, 4-bromo- | HCID 74654 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-(4-bromophenyl)acetate | HCID 316783 | 100.1% |
Reaction Steps
Acetyl chloride (10 g) was added dropwise over 5 minutes to methanol (250 mL). After 5 minutes, (4-bromo-phenyl)-acetic acid (15 g) was added. The resulting mixture was stirred for 96 hours, concentrated and the residue azeotroped with toluene (×2) to give the subtitle compound as a yellow oil (16 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951954B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-b04f42c4a6c243de99ce225f456714d3 |
| Source note | uspto-grants-2011_05 |