Borane;tetrahydrofuran → HCID 67165309, compound

Participants

Reaction Steps

Borane-tetrahydrofuran complex (1M in tetrahydrofuran) (1.0 mL) was added to a solution of [3′-(1,3-dihydro-iso-indol-2-ylmethyl)-biphenyl-4-yl]-acetic acid (0.444 g) in tetrahydrofuran (30 mL) and stirred at room temperature, under nitrogen, for 3 hours, then evaporated The residue was dissolved in methanol and loaded onto a conditioned SCX cartridge (10 g Varian). The cartridge was washed with methanol (3×20 mL) and then eluted with methanolic ammonia solution (2×20 mL). The combined eluents were concentrated to give the subtitle compound as a dark brown oil (165 mg)

Provenance & Evidence