HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Phenylenediacetic acid → (3-{[2-(2-Methoxy-phenyl)-ethylcarbamoyl]-methyl}-phenyl)-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Phenylenediacetic acid | HCID 29788 | — |
| Reactant | 2-Methoxyphenethylamine | HCID 74896 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Product | (3-{[2-(2-Methoxy-phenyl)-ethylcarbamoyl]-methyl}-phenyl)-acetic acid | HCID 67164052 | 30.5% |
Reaction Steps
Prepared from (3-carboxymethyl-phenyl)-acetic acid (2.00 g), 2-(2-methoxy-phenyl)-ethylamine (1.60 g), 1-hydroxybenzotriazole (1.40 g), Hunigs base (1.8 mL), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (2.00 g), using the method of Example 44 (step a), to give 1.03 g of the sub-titled compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07951954B2 |
| Source dataset | uspto-grants-2011_05 |
| ORD ID | ord-e5fedfd554524d778c202074a021fdac |
| Source note | uspto-grants-2011_05 |