2-(Trifluoromethyl)phenyl isocyanate → 4-Hydroxy-3-(2'-trifluoromethylphenylcarbamoyl)coumarin

Participants

Reaction Steps

According to the procedure of example 17, 4-hydroxycoumarin (2.00 g. 12.8 mmol) and 2-trifluoromethylphenylisocyanate(1.93 ml, 12.8 mmol) were reacted in the presence of triethylamine (0.05 ml) to generate the title compound as an off-white solid, mp 157°-159°]C., (2.2 g, 6.30 mmol, 49.3%). Analysis: Calculated for C17H10NO4F3 : C, 58.45; H, 2.86; N, 4.01. Found: C, 58.47; H, 3.04; N, 4.02. 1H NMR (CDCl3): 8.06 (d, J=7.8 Hz, 2H), 7.70 (d, J=8.8 Hz, 2H), 7.62 (t, J=7.8 Hz, 1H), 7.38 (m, 3H).

Provenance & Evidence