HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenethylamine → Armodafinil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenethylamine | HCID 7408 | — |
| Reactant | Modafinil acid | HCID 3085267 | — |
| Reactant | HCID 178514057 | HCID 178514057 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Armodafinil | HCID 9690109 | — |
Reaction Steps
U.S. Pat. No. 4,927,855 describes the preparation of the levorotatory enantiomer of modafinil by chiral resolution of the 2-[(diphenylmethyl)sulfinyl]acetic acid with α-methylbenzyl amine. After recovery and amidation of the enantiomerically pure acid, (−) modafinil was obtained as white crystals by crystallization from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048222B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-58141b0965b24d8e90d911acee886957 |
| Source note | uspto-grants-2011_11 |