Pyridine → HCID 178444542, compound

HRID 553370Notes

Reaction equation

HRID 553370 reaction equation
S(Cl)([Cl:3])=O.[CH2:5]([C@H:10]1[CH2:15][CH2:14][C@H:13]([C:16]([OH:18])=O)[CH2:12][CH2:11]1)[CH2:6][CH2:7][CH2:8][CH3:9].N1C=CC=CC=1>C1(C)C=CC=CC=1>[CH2:5]([C@H:10]1[CH2:15][CH2:14][C@H:13]([C:16]([Cl:3])=[O:18])[CH2:12][CH2:11]1)[CH2:6][CH2:7][CH2:8][CH3:9]

Participants

5

Reactant 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 178444557HCID 178444557, compound

Product 1

HCID 178444542HCID 178444542, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

20 mL of thionyl chloride was added dropwise to a mixture containing 20.0 g (0.1 mol) of trans-4-pentylcyclohexanecarboxylic acid represented by the following formula (b-i), 0.5 mL of pyridine and 300 mL of toluene in a nitrogen atmosphere, and the mixture was stirred under heating to 80° C. or less for 1 hour. The solvent was distilled off under reduced pressure to provide trans-4-pentylcyclohexanecarboxylic acid chloride.

Workup

  1. temperatureunder heating to 80° C. or less for 1 hour
  2. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-ca2f9cd410f44863bb2746a888088958
Source dataset
uspto-grants-2011_11
Patent number
US08048335B2

Reaction notes

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