Ethylenediamine → HCID 24752057, compound

Participants

Reaction Steps

The title compound was prepared in three steps as described in Procedure D. In the first step, ethylenediamine was reacted in acetonitrile with 2,4,5-trifluorobenzoylchloride (2 eq) in the presence of TEA to give the N,N′-dibenzoylated ethylenediamine upon aqueous work-up. After the last step (reaction with cyanogen bromide, performed at 200° C. for 60 min using MW heating), the precipitated solid was filtered off and recrystallized to give the title compound as the hydrogen bromide salt. MS (ES+) m/z 374 ([M+1]+, 100); HR-MS: 374.1086 ([M+1]+, C17H14F6N3; calc. 374.10919).

Provenance & Evidence