HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → HCID 57618621, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Pyrrolidin-1-yl-3a,4,5,6,7,7a-hexahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid ethyl ester | HCID 86761431 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 57618621 | HCID 57618621 | — |
Reaction Steps
In stage 3, 5-acetyl-7° a.-pyrrolidin-1-yl-3a,4,5,6,7,7a-hexahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid ethyl ester (B) is reacted in a reaction medium, preferably selected from the group consisting of acetonitrile, dichloromethane, chloroform, dimethylformamide, dimethylacetamide, dimethyl sulfoxide and corresponding mixtures, in the presence of an organic acid, preferably in the presence of trifluoroacetic acid, with refluxing to yield the compound 5-acetyl-4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine-3-carboxylic acid ethyl ester (C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08048879B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-7df0b1446b174e3a9d63d49c8c88ace9 |
| Source note | uspto-grants-2011_11 |