Piperazin-4-ylacetophenone → HCID 57434474, compound

HRID 553426Notes

Reaction equation

HRID 553426 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]2[O:14][N:15]=[C:16]([C:17]([OH:19])=O)[C:10]=2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:20][C:21]([C:23]1[CH:28]=[CH:27][C:26]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[CH:25][CH:24]=1)=[O:22]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]2[O:14][N:15]=[C:16]([C:17]([N:32]3[CH2:31][CH2:30][N:29]([C:26]4[CH:25]=[CH:24][C:23]([C:21](=[O:22])[CH3:20])=[CH:28][CH:27]=4)[CH2:34][CH2:33]3)=[O:19])[C:10]=2[CH2:9]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 97269Piperazin-4-ylacetophenoneHCID 576186225-(1,1-Dimethylethyl) 6,7-dihydroisoxazolo[4,5-c]pyridine-3,5(4H)-dicarboxylate

Product 1

HCID 57434474HCID 57434474, compoundYield 42.4%

Procedure

In a manner similar to general method 1, 1.1 g (4.1 mmol) of 6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-3,5-dicarboxylic acid 5-tert-butyl ester were reacted with 838 mg (4.1 mmol) of 4-piperazinoacetophenone to yield 790 mg (42% of theoretical) of 3-[4-(4-acetyl-phenyl)-piperazine-1-carbonyl]-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester, which were obtained in the form of a yellow-orange oil.

Sources & evidence

ORD record
ord-e9dc8af404b445b5861972a4d0d1785d
Source dataset
uspto-grants-2011_11
Patent number
US08048879B2

Reaction notes

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