反应详情

A mixture of (+)(2aS,4R)-6-(3-isoxazolyl)-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole (180 mg, 0.5 mmol) and 1 g of MnO2 in 40 mL of CH2Cl2 was sonicated at 50-55 KHz for 2 hr. The reaction mixture warmed to reflux during the time period. The reaction mixture was filtered through a celite pad and the filtrate was concentrated to dryness in vacuo. The residue was chromatographed (flash column, silica gel, ethyl acetate) to provide 50 mg of the isoxazole indole product as an oil. MS (FD) 323

1. customwas sonicated at 50-55 KHz for 2 hr
2. temperatureThe reaction mixture warmed
3. temperatureto reflux during the time period
4. filtrationThe reaction mixture was filtered through a celite pad
5. concentrationthe filtrate was concentrated to dryness in vacuo
6. customThe residue was chromatographed (flash column, silica gel, ethyl acetate)