Hydrochloric Acid → HCID 57671688, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(4-hydroxy-1-methyl-2-oxo-7-(2-(trimethylsilyl)ethynyl)-1,2-dihydro-1,8-naphthyridine-3-carboxamido)acetic acid (183 mg, 490 μmol, Example 19 (b)) in MeOH (5 mL) and THF (5 mL) was added potassium carbonate (339 mg, 2450 mmol), and the reaction mixture was stirred at 23° C. for 23 hours. The mixture was acidified with concentrated HCl, and filtered. The filter cake was washed with water (10 mL), Et2O (10 mL) and DCM (10 mL), and dried in vacuo to give the title compound as a brown solid. MS (ESI, pos. ion) m/z: 302 (M+1). 1H NMR (400 MHz, DMSO-d6) δ ppm: 10.22-10.52 (m, 1 H), 8.43 (d, J=8.0 Hz, 1 H), 7.54 (d, J=8.2 Hz, 1 H), 4.74 (s, 1 H), 4.14 (d, J=5.5 Hz, 2 H), 3.64 (s, 3 H).

Provenance & Evidence