2-Chloro-4-methylpyrimidine → HCID 57671639, compound

Participants

Reaction Steps

The title compound was prepared from tert-butyl 2-(4-hydroxy-1-methyl-2-oxo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxamido)acetate (Example 26 (h)) and 2-chloro-4-methylpyrimidine analogously to the procedures described for the preparation of Example 26 (i) and Example 26 (k), or Example 21 (b). MS (ESI, pos. ion) m/z: 370 (M+1). 1NMR (400 MHz, DMSO-d6) δ ppm: 10.41 (s, 1 H), 9.65 (s, 1 H), 9.24 (s, 1 H), 8.80 (d, J=4.9 Hz, 1 H), 7.41 (d, J=4.9 Hz, 1 H), 4.13 (d, J=5.3 Hz, 2 H), 3.74 (s, 3 H), 2.59 (s, 3 H).

Provenance & Evidence