Potassium Carbonate → HCID 57742969, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2-(3-ethoxy-N-methyl-3-oxopropanamido)-3,4-difluorobenzoate. At 0° C., a suspension of methyl 3,4-difluoro-2-(methylamino)benzoate (1.10 g, 5.47 mmol) and potassium carbonate (0.98 g, 7.1 mmol) in THF (10 mL) was treated dropwise with ethyl 3-chloro-3-oxopropanoate (0.90 mL, 7.11 mmol). The mixture was warmed to 24° C., stirred for 3 hours, diluted with water, and extracted with EtOAc. The combined organic layers were dried over MgSO4, and evaporated. Purification by flash chromatography (EtOAc/hexanes) gave the title compound. MS (ESI) m/z: Calculated; 315.3: Observed; 316.1. 1H.NMR (300 MHz, CDCl3) δ ppm 7.81-7.91 (1H, m), 7.28-7.37 (1H, m), 4.12 (2H, q, J=7.1 Hz), 3.92 (3H, s), 3.23 (3H, s), 3.10 (2H, s), 1.23 (3H, t, J=7.2 Hz).

Provenance & Evidence