Phosgene → HCID 57671538, compound

HRID 553549Notes

Reaction equation

[Cl:1][C:2]1[N:14]=[CH:13][C:5]2[N:6]([CH3:12])[C:7](=[O:11])O[C:9](=[O:10])[C:4]=2[CH:3]=1.ClC1C=[C:18](C(NC)=CN=1)[C:19]([OH:21])=[O:20].[C:27](Cl)(Cl)=O>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:13][N:14]=1)[N:6]([CH3:12])[C:7](=[O:11])[C:18]([C:19]([O:21][CH3:27])=[O:20])=[C:9]2[OH:10]

Participants

Reactant 3

HCID 6371Phosgene

HCID 57671532HCID 57671532, compound

HCID 576716716-Chloro-1-methyl-2H-pyrido[3,4-d][1,3]oxazine-2,4(1H)-dione

Product 1

HCID 57671538HCID 57671538, compound

Procedure

6-Chloro-1-methyl-1H-pyrido[3,4-d][1,3]oxazine-2,4-dione. The title compound was prepared analogously to method 6(b) from 2-chloro-5-(methylamino)isonicotinic acid and phosgene.

Sources & evidence

ORD record: ord-ce064a11a949416c96653fc4507c2b6b
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08048894B2

Reaction notes

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