Phenylboronic Acid → HCID 54740912, compound

Participants

Reaction Steps

Methyl 4-(4-hydroxy-1-methyl-2-oxo-6-phenyl-1,2-dihydroquinolin-3-yl)-4-oxobutanoate. The title compound is prepared by Palladium mediated Suzuki cross coupling reaction of phenyl boronic acid and methyl 4-(4-hydroxy-6-iodo-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)-4-oxobutanoate (Method 4) according to the procedure set forth in Miyaura, N.; Suzuki, A. Chem. Rev., 95, 2457-83 (1995). Alternatively, the title compound is prepared by Palladium mediated Stille cross coupling reaction of tributyl(phenyl)stannane and methyl 4-(4-hydroxy-6-iodo-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)-4-oxobutanoate according to the procedure set forth in Stille, J. K. Agnew. Chem. Int. Ed. Engl., 25, 508-24 (1986).

Provenance & Evidence