HCID 57742965, compound → HCID 54740924, compound

Participants

Reaction Steps

Methyl 5-hydroxy-6-(4-methoxy-4-oxobutanoyl)-8-methyl-7-oxo-7,8-dihydro-1,8-naphthyridine-3-carboxylate. The title compound is prepared by metal mediated carbonylation of methyl 4-(4-hydroxy-6-iodo-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl)-4-oxobutanoate (Method 4) with carbon monoxide in MeOH according to the procedure set forth in Tsuji, J. Palladium Reagents and catalysts: Innovations in Organic Synthesis Publisher: (Wiley, Chichester, UK), 340-45 (1995).

Provenance & Evidence