Triethylamine → HCID 86635184, compound

Participants

Reaction Steps

Compound 2.8 (200 mg, 0.623 mmol), 3-{(3R,4R)-1-[(2S)-2-amino-3-methylbutyl]-3,4-dimethylpiperidin-4-yl}phenol (J) (181 mg, 0.623 mmol) and BOP reagent (275 mg, 0.623 mmol) were dissolved in THF (20 mL). Triethylamine (1 mL) was added and the solution was stirred at room temperature for 3 h. The solution was extracted with CH2Cl2 and saturated NaHCO3 solution. The organic layer was dried and purified by column chromatography to afford 250 mg, (68%) of 2.9.

Provenance & Evidence