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HRID553571

反应详情

EQUATION

反应方程式

HRID 553571 的结构方程式

REACTANTS

反应物

2
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)c1c(C)cccc1OCCO[C@@H]1CCC[C@H](OCc2nc(-c3cccc(C)c3)oc2C)C1
HCID59820046

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cccc(-c2nc(CO[C@H]3CCC[C@@H](OCCOc4cccc(C)c4C(=O)O)C3)c(C)o2)c1
HCID59820060

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CO
溶剂HCID887

Methanol

CH4O

结构：CCOC(C)=O.Cl
溶剂HCID21866389

未命名化合物

CONDITIONS

反应条件

温度
80 °C

PROCEDURE

实验过程

Unpurified ethyl (1R,3S)-2-methyl-6-{2-[3-(5-methyl-2-m-tolyloxazol-4-ylmethoxy)cyclohexyloxy]ethoxy}benzoate are dissolved in 3 ml of methanol, and 0.25 ml of a 5 N sodium hydroxide solution are added. The mixture is stirred at 60° C. for 8 h and at 80° C. for 12 h. After cooling, the mixture is taken up in 2N HCl/ethyl acetate, the organic phase is dried over sodium sulfate and the solvent is removed under reduced pressure. The residue is purified by RP-HPLC. This gives (1R,3S)-2-methyl-6-{2-[3-(5-methyl-2-m-tolyloxazol-4-ylmethoxy)cyclohexyloxy]ethoxy)benzoic acid as a colorless oil. C28H33NO6 (479.58), MS (ESI). 480 (M+H+).

WORKUP

后处理

  1. temperatureAfter cooling
  2. dry with materialthe organic phase is dried over sodium sulfate
  3. customthe solvent is removed under reduced pressure
  4. customThe residue is purified by RP-HPLC