Sulfuric Acid → N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-pyrazole-3-carboxamide hydrogensulfate

HRID 55363Notes

Reaction equation

HRID 55363 reaction equation
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].[N:6]1([NH:12][C:13]([C:15]2[C:19]([CH3:20])=[C:18]([C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[N:17]([C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][C:29]=3[Cl:35])[N:16]=2)=[O:14])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>CC(C)=O>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[N:6]1([NH:12][C:13]([C:15]2[C:19]([CH3:20])=[C:18]([C:21]3[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][CH:26]=3)[N:17]([C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][C:29]=3[Cl:35])[N:16]=2)=[O:14])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 104850Rimonabant

Product 1

HCID 25026422N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-pyrazole-3-carboxamide hydrogensulfate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

0.018 ml of concentrated sulfuric acid are added to a solution of 0.30 g of the compound obtained in example 195 in 3 ml of acetone. The white crystals formed are filtered off, washed with acetone and then ether, and dried under vacuum to give 0.31 g of the expected salt. m.p.=240° C.

Workup

  1. customThe white crystals formed
  2. filtrationare filtered off
  3. washwashed with acetone
  4. dry with materialether, and dried under vacuum

Sources & evidence

ORD record
ord-58378ffaacc74b40a1d0fda56f1038b3
Source dataset
uspto-grants-1997_04
Patent number
US05624941

Reaction notes

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