HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 553663Generated: October 26, 2026
Lithium Hydroxide → 5-(4-Bromophenyl)-3-methyl-1,2-oxazole-4-carboxylic acid
https://huagongshe.com/reaction/553663
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate | HCID 56604575 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(4-Bromophenyl)-3-methyl-1,2-oxazole-4-carboxylic acid | HCID 56604559 | — |
Reaction Steps
Lithium hydroxide (2 g, 48 mmol) was added to a solution of 5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid methyl ester (39 mmol) in methanol (50 mL) and water (10 mL), and the reaction was stirred at 60° C. for 1 hour. Acidic work-up gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08048902B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-62ee334cd205489f819751d1f9042218 |
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| Source note | uspto-grants-2011_11 |
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