HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → Ethyl 4-(2-pyrimidinylimino)-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 2-Aminopyrimidine | HCID 7978 | — |
| Reactant | Ethyl 4-oxo-1-piperidinecarboxylate | HCID 34767 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Product | Ethyl 4-(2-pyrimidinylimino)-1-piperidinecarboxylate | HCID 21460901 | 101.4% |
Reaction Steps
A mixture of 34 g of ethyl 4-oxo-1-piperidinecarboxylate, 20 g of 2-pyrimidinamine, 8 drops of acetic acid and 103.5 ml of methylbenzene was stirred for 28 hours at reflux temperature using a water-separator. The reaction mixture was evaporated, yielding 50 g of ethyl 4-(2-pyrimidinylimino)-1-piperidinecarboxylate as a residue (interm. 18).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05624952 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-1a0ae741972c4b9d8242149b8e628c91 |
| Source note | uspto-grants-1997_04 |