Ethyl 2-(4-bromophenyl)-2-methylpropanoate → 2-(4'-{4-[1-(2-Fluoro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-2-methyl-propionic acid ethyl ester

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 2-(4-bromophenyl)-2-methylpropanoate	HCID 11277257	—
Reactant	{3-Methyl-5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-isoxazol-4-yl}-carbamic acid 1-(2-fluoro-phenyl)-ethyl ester	HCID 67352155	—
Product	2-(4'-{4-[1-(2-Fluoro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-2-methyl-propionic acid ethyl ester	HCID 67351644	—

Reaction Steps

Prepared as described in Example 36, Step 6 using {3-methyl-5-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-isoxazol-4-yl}-carbamic acid 1-(2-fluoro-phenyl)-ethyl ester and 2-(4-bromo-phenyl)-2-methyl-propionic acid ethyl ester; purification by preparative HPLC was utilized.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08048902B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-d5da575552344dd2a66cb87591df1846
Source note	uspto-grants-2011_11